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March 1, 2017, Vol 74, No. 3, Pages 253-364

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
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JAMA Neurol. 2017;74(3):253. doi:10.1001/jamaneurol.2016.3984
Viewpoint

Imaging as the Nidus of Precision Cerebrovascular HealthA Million Brains Initiative

Abstract Full Text
JAMA Neurol. 2017;74(3):257-258. doi:10.1001/jamaneurol.2016.4896

This Viewpoint describes the importance of aggregating imaging data to help improve cerebrovascular health.

Editorial

Mechanical Thrombectomy for Acute Ischemic StrokeAre We Done?

Abstract Full Text
JAMA Neurol. 2017;74(3):259. doi:10.1001/jamaneurol.2016.5322

Are miRNAs Appropriate Biomarkers for Radiologic Measures of Tissue Injury in Multiple Sclerosis?

Abstract Full Text
JAMA Neurol. 2017;74(3):260-261. doi:10.1001/jamaneurol.2016.5384

Risk of Multiple Sclerosis After a Clinically Isolated SyndromeFrom Magnetic Resonance Imaging to Oligoclonal Bands to Activated T Cells

Abstract Full Text
JAMA Neurol. 2017;74(3):262-263. doi:10.1001/jamaneurol.2016.5143

Multiple Sclerosis—A Tuning Fork Still Required

Abstract Full Text
JAMA Neurol. 2017;74(3):264-265. doi:10.1001/jamaneurol.2016.5126

Association of Periodic Discharges With Reduced Brain Tissue OxygenationNo Longer Straddling the Fence?

Abstract Full Text
JAMA Neurol. 2017;74(3):266-267. doi:10.1001/jamaneurol.2016.5319
Original Investigation

Combined Intravenous Thrombolysis and Thrombectomy vs Thrombectomy Alone for Acute Ischemic StrokeA Pooled Analysis of the SWIFT and STAR Studies

Abstract Full Text
has active quiz
JAMA Neurol. 2017;74(3):268-274. doi:10.1001/jamaneurol.2016.5374

This study examines whether treatment with intravenous thrombolysis before mechanical thrombectomy with a stent retriever is beneficial in patients undergoing mechanical thrombectomy.

Association Between Serum MicroRNAs and Magnetic Resonance Imaging Measures of Multiple Sclerosis Severity

Abstract Full Text
JAMA Neurol. 2017;74(3):275-285. doi:10.1001/jamaneurol.2016.5197

This cohort study compares the expression of serum microRNA with findings shown on magnetic resonance imaging in evaluating disease severity in patients with multiple sclerosis.

Soluble CD27 Levels in Cerebrospinal Fluid as a Prognostic Biomarker in Clinically Isolated Syndrome

Abstract Full Text
JAMA Neurol. 2017;74(3):286-292. doi:10.1001/jamaneurol.2016.4997

This study investigates whether the T-cell activation marker soluble CD27 measured in cerebrospinal fluid of patients at the time of a first attack is associated with a subsequent diagnosis of MS and a higher relapse rate.

Assessment of Early Evidence of Multiple Sclerosis in a Prospective Study of Asymptomatic High-Risk Family Members

Abstract Full Text
JAMA Neurol. 2017;74(3):293-300. doi:10.1001/jamaneurol.2016.5056

This cohort study investigates the prevalence of brain magnetic resonance imaging and subclinical abnormalities among asymptomatic individuals at risk for multiple sclerosis.

Electroencephalographic Periodic Discharges and Frequency-Dependent Brain Tissue Hypoxia in Acute Brain Injury

Abstract Full Text
JAMA Neurol. 2017;74(3):301-309. doi:10.1001/jamaneurol.2016.5325

This cohort study assesses whether distinct EEG periodic discharges can be identified that are associated with brain tissue hypoxia, a measure of ongoing brain injury in comatose patients with subarachnoid hemorrhage.

Duration and Pathologic Correlates of Lewy Body Disease

Abstract Full Text
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JAMA Neurol. 2017;74(3):310-315. doi:10.1001/jamaneurol.2016.4926

This cohort study identifies pathologic correlates of disease duration in individuals with Lewy body disease.

Incidence of Recurrence in Posterior Circulation Childhood Arterial Ischemic Stroke

Abstract Full Text
JAMA Neurol. 2017;74(3):316-323. doi:10.1001/jamaneurol.2016.5166

This cohort study investigates the incidence of the recurrence of childhood arterial ischemic stroke in the posterior and anterior circulations to determine if the risk differs between the 2 locations.

Surgical Treatment of Nonlesional Neocortical EpilepsyLong-term Longitudinal Study

Abstract Full Text
JAMA Neurol. 2017;74(3):324-331. doi:10.1001/jamaneurol.2016.4439

This study evaluates the long-term surgical outcome to identify possible prognostic factors in patients with nonlesional neocortical epilepsy.

Association Between Mentally Stimulating Activities in Late Life and the Outcome of Incident Mild Cognitive Impairment, With an Analysis of the APOE ε4 Genotype

Abstract Full Text
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JAMA Neurol. 2017;74(3):332-338. doi:10.1001/jamaneurol.2016.3822

This population-based cohort study examines the association between mentally stimulating activities in late life and the risk of incident mild cognitive impairment and evaluates the influence of the APOE ε4 genotype.

Review

Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E ε4 CarriersA Review

Abstract Full Text
JAMA Neurol. 2017;74(3):339-347. doi:10.1001/jamaneurol.2016.4899

This review assesses interactions among docosahexaenoic acid, apolipoprotein E ε4 status, and stage of pathologic changes of Alzheimer disease to explain the mixed results of ω-3 fatty acid supplementation reported in the literature.

Clinical Pathologic Conference

A Woman in Her 60s With Chronic Meningitis

Abstract Full Text
JAMA Neurol. 2017;74(3):348-352. doi:10.1001/jamaneurol.2016.2388

This case report describes the process of determining which pathogen caused a woman in her 60s to present with symptoms of chronic meningitis.

Images in Neurology

Intracranial Tuberculoma in a Patient With Untreated Human Immunodeficiency Virus

Abstract Full Text
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JAMA Neurol. 2017;74(3):356-357. doi:10.1001/jamaneurol.2016.3362

This case report describes a woman in her 40s who was admitted after 4 months of headache, fatigue, and weight loss.

JAMA Neurology Clinical Challenge

Improved Muscular Weakness During Asthma Exacerbation

Abstract Full Text
JAMA Neurol. 2017;74(3):353-354. doi:10.1001/jamaneurol.2016.4069

A 48-year-old man had muscular weakness and restricted ability to walk since infancy, but during an asthma attack, the patient was able to climb the stairs, rise from the floor, and walk several kilometers. What is your diagnosis?

Research Letter

Association of Extension of Cervical Cord Lesion and Area Postrema Syndrome With Neuromyelitis Optica Spectrum Disorder

Abstract Full Text
JAMA Neurol. 2017;74(3):359-361. doi:10.1001/jamaneurol.2016.5441

This study evaluates whether longitudinally extensive cervical cord lesions extending to or accompanied by area postrema/dorsal medulla lesions on magnetic resonance imaging are specific for neuromyelitis optica spectrum disorders.

Comment & Response

Stroke Diagnosis and Treatment in the Emergency Department

Abstract Full Text
JAMA Neurol. 2017;74(3):361. doi:10.1001/jamaneurol.2016.5558

Stroke Diagnosis and Treatment in the Emergency Department

Abstract Full Text
JAMA Neurol. 2017;74(3):362. doi:10.1001/jamaneurol.2016.5561

Stroke Diagnosis and Treatment in the Emergency Department—Reply

Abstract Full Text
JAMA Neurol. 2017;74(3):362-363. doi:10.1001/jamaneurol.2016.5564

Neurofilament Protein and Antineurofilament Antibodies Following Traumatic Brain Injury

Abstract Full Text
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JAMA Neurol. 2017;74(3):363. doi:10.1001/jamaneurol.2016.5908

Neurofilament Protein and Antineurofilament Antibodies Following Traumatic Brain Injury—Reply

Abstract Full Text
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JAMA Neurol. 2017;74(3):363-364. doi:10.1001/jamaneurol.2016.5905
Correction

Misspelling of Author’s Surname

Abstract Full Text
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JAMA Neurol. 2017;74(3):364. doi:10.1001/jamaneurol.2016.6048
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2017;74(3):255. doi:10.1001/jamaneurol.2016.3985
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